Sunday, March 18, 2012

The Semmelweis Reflex: Why May We Be Wrong?


 March 18, 2012

Not long ago I was thrilled by this story of a Hungarian doctor who lived in the heat of the scientific revolution and seemed to have gone so far ahead of his time that it destroyed his life.

His name was Ignaz Semmelweis, he was 29 when in 1847 he began his work as an assistant to the professor of the maternity clinic at the Vienna General Hospital in Austria (Benedek 1983). Just at the time there was a sharp rise in death rates among midwives as well as female patients right after giving birth. The nature of what was called puerperal, or childbed fever was attributed to very specific causes that, as it was believed, varied uniquely from case to case and could not be explained by a universal theory since every human being is unique.

Semmelweis was the only physician to propose that all the cases went down to one cause – the lack of cleanliness leading to the accumulation of cadaverous particles on one’s hands and causing contamination of a person who comes in contact with them (Benedek 1983). He observed that many doctors were alternating the delivery of babies with performing autopsies in post-mortem examinations. Ultimately, he suggested that the doctors and midwives simply wash their hands in chlorine lime solutions before each procedure (Hanninen 1983:370).

Although the results were immediate (the mortality rates dropped by 90% within months) Semmelweis soon had faced fierce opposition on the part of the major medical community as the very idea of causing death by a simple touch was at the time perceived similarly to witchcraft and sorcery! Soon he lost his job at the clinic, though for political reasons, and moved back to Hungary where he wrote down his hypotheses in his book Etiology, Concept and Prophylaxis of Childbed Fever (1859).

To understand such fierce reaction from doctors it is important to look back at the time when this was happening. The early 19th century saw the blossoming of the industrial revolution, with the shift of the scientific paradigm from the idealistic to the mechanical worldview established by Isaac Newton. The world had begun to be viewed as a gigantic mechanism whose capstone was PHYSICAL FORCE, which implied that the extent of physical damage could only be measured in physical units. 

Simultaneously, the newly-formed scientific society had begun to move away from the medieval interpretations and practices of curing diseases. With the triumph of reason methods such as herbs, health potions, sorcery along with prayer, sprinkling of holy water were now deemed as irrational and soon became tabooed by materialists. Inevitably, those who practiced such methods were ridiculed. So was Semmelweis who in the eyes of his contemporaries, all medical intellectuals and renowned practitioners, was reverting to medieval times. He was criticized, mocked and harassed by the medical community. Moreover, as K. Carter notes, some doctors were offended at the suggestion that they should wash their hands; they felt that their social status as gentlemen was inconsistent with the idea that their hands could be unclean (Carter 2005).

So it wasn’t until several decades later that Louis Pasteur confirmed the germ theory that led to the establishing of bacteriology as a science and acquitted Semmelweis in the eyes of the scientific community. Unfortunately, Semmelweis wasn’t able to enjoy the celebration of his ideas. After two weeks in the mental asylum where he had been placed at the urging of his counterparts who believed him to have lost his mind he allegedly died of septicaemia, the very disease he had fought for so long. According to other reports, he was murdered by the guards.

There is no doubt that the Enlightment era advanced the world a great deal: steam engine, lever, gear wheel, thermodynamics laws – all this was great. However, these inventions do not apply to everything there is. Battling one superstition those scientists fell into another, not realizing that human organism is a way more complicated structure then they thought. Now we live in a materialistic humanistic society where scientists believe that G-d is a superstition, not only He but many other things such as marriage, premarital purity and physical abstention. But can it turn out that we are killing a woman in labor with our unclean hands? While for many people it’s not a question anymore, others should stop for a moment and seriously ask themselves: may we be wrong?

Read also: 
Medical History: Semmelweis and the Great Handwashing Mystery

15 comments:

  1. What I can say about this article is that it's a very sad story about the whole philosophy of our world. This scientist, Semmelweis, was very clever guy, but he was alone. And this very problem grieves me all the time: why is it so hard to prove something, if you have no supporters, even with real evidence? This man faced this problem. People are usual primitive animals sometimes, they are afraid of any changes in their lifes and minds. They can accept an idea easily only when it doesn't break their comfort or dignity. But, unfortunately, doctors in that time were too proud... How they could be so stupid? I don't understand.
    So, and what about our times? Honestly, I'm not realy good in this sphere, but I suppose that in modern scientific society things happen more easy. There are many researches in medicine, and their results help to make a progress in real curing. Of course, there are a lot of other problems, such as bad educational level, lack of money and so on... But it's not about this discussion. So, I believe that science men are working thoroughly and try to help each other. But there is another problem: people carry on the tradition of distrust the official medicine. Many of them prefer services of different "wizards", "witches", fortune-tellers and healers. Why do they go to the small darkened rooms with cheap childish set (candles, magic balls, various cards and so on)instead of modernized clinics and hospitals? Why do they trust their health and life to crazy dishevelled men in black rodes instead of intelligent neat well-educated doctors? I don't understand and I don't know how to fight it. But we need to fight it, I think. The humanity can't develop and overcome the disbalance while one part is going ahead with other part is trying to preserve their minds on some ancient level.

    Ann Shchekotihina

    ReplyDelete
    Replies
    1. Very expressive statement. It looks like you have been imbued by the story which shows that the article has been carefully read and and well understood. Apart from certain inaccuracies in wording and grammar it is a quality response.
      As for your viewpoint that science has changed for better, I believe it's true to an extent that scientists no longer claim to know it all like they used to. However there's still a lot of rigid old-time scholars who deny everything that science can't explain.

      Delete
  2. To my mind this article is example of numerous stories about outstanding men (scientists, philosophers, writers and so on) who ware genius of their time. With such kind of contemporary society prejudice (which is described in the article and in the Ann’s comment) Leonardo da Vinci, Galileo Galilei, Nikola Tesla and many others were faced. One of the main drawbacks of human being nature is to condemn everything that majority can not understand. As it happened with Ignaz Semmelweis. How it is awfully that the new idea or the whole theory are less important than public image of stiff doctors group. (“they felt that their social status as gentlemen was inconsistent with the idea that their hands could be unclean”).
    And what is about our days? I suppose that modern science is more flexible to new ideas than it was 200 years ago. As I know it is possible for beginners in science to propose their ideas, plans, and developments on different levels. They can state their views and projects in universities, on conferences, try to get some research grant. In our country there are a lot of workgroup support government programs. For example – “Innovation projects of young scientists” set up by The Russian Academy of Sciences.
    But this coin has the other side. Not every idea or project are paying business for businessmen. It’s no secret that some of medicament producer will be against of some universal medicine for cold, for example. Because in such a case they will lose an opportunities to sell their “hollow” drugs. But it is a question of business not science.
    Summing up all I wanted to say that in our days the scientist are more qualified and competent than 200 years ago, so there a lot of foundation to trust them.

    Sveta Kurochkina

    ReplyDelete
  3. Quite an interesting and sad story. I would not say that everything is as bad as it was back then. However, there ARE experiences to be discussed… as they say, there is always a way to go (ahead)
    In our human world far inhuman attitude reigns in human-human relationships, strange as it may seem. Human’s life is valueless, not valuable, or precious, but quite the reverse – it is not worth a dime. People became so accustomed to a death - just as Jesus Christ foretold that “because of the increasing of lawlessness the love of the great number will cool off”. (Mathew 24:12) But the most terrible fact is that physicians themselves became indifferent to people’s death too.

    ReplyDelete
  4. Today a very similar situation can be observed in the sphere of blood transfusion. Experiments with it started in the beginning of XVI century. The first 46 years of blood using both physicians and the public thought stored blood to be safer than it was indeed. At that time physicians had poor knowledge of the liquid being used and poured to one and all, the method practiced during wars, without testing it. But in the year 1960 New York State Journal of Medicine announced: “Blood is dynamite! It can do a great deal of good or a great deal of harm.” It was found out that blood transfusion implies large number of dangers. First of all, blood is a carrier of such dangerous infectious diseases as AIDS, hepatitis A,B,C,D and so on, which were being discovered in the course of time, and these “are not the whole alphabet of hepatitis viruses; yet others may emerge." (the Harvard Medical School Health Letter (November 1989) ) For example, according to WHO 5 000 people annually get the hepatitis C infection from donor blood and injections. New and new infections that cannot be detected in the initial phase (such as Chagas disease). In addition there is a great probability of allergic reactions. Blood is an alien element for our organism and our immune system meant for fighting foreign elements actively resist foreign cells. To make organism accept them, physicians suppress the immune system. As a result such patients are more vulnerable to various infectious diseases.

    ReplyDelete
  5. One more danger related with blood transfusion is so called massive transfusion syndrome. In this case blood is transfused when a person doesn’t have a need in transfusion or too much blood is being transfused. This often leads to death.
    But fortunately, there were and there are people of “bright mind” whose desire to provide more qualitative treatment and professionalism gained the upper hand over pride and negligence. They found different ways to avoid using blood, including medicines that could be used instead of blood. They are such plasma expanders as brine, Ringer’s solution, dextran; red cell increasing medicines, e.g. erythropoietin. What more, many physicians acknowledge that bloodless operation requires a higher level of professional mastery because the amount of lost during operation blood depends fully on the physician. To help them in this work such apparatus as electrocoagulator , reinfusion apparatus and hemodilution technique. Prof. Philippe Van der Linden states that in view of the better patient care and treatment cost saving own blood “is not an option, it’s a must”.
    The most attention-worth fact is that transfusion-alternative strategies are “simple, safe and effective”, the fact acknowledged by many specialists. They have a great number of advantages. They are simple in using and cheap, the mortality rate is significantly lower, patient is recovered and out of hospital much faster, and what is highly important is they are qualitative and safe.

    ReplyDelete
  6. According to the words of Prof. Roland Hetzer from German Heart Institute today at least 80 percent of patients refuse donor blood. Jehovah’s Witnesses are among them. And mostly due to their efforts alternatives to blood transfusion are now used in 150 counties by 10 000 leading medical specialists. Doctor Denton Cooley from Texas Heart Institute said: "We became so impressed with the results [from using the nonblood plasma expanders] on the Jehovah's Witnesses that we started using the procedure on all our heart patients." While Witnesses will not receive blood for religious reasons based on the biblical point of view on blood, many agrees that such a firm position safe them from multiple infectious diseases and get medical care of higher quality.
    Unwittingly a question arises: “If these alternative strategies are “simple, safe and effective”, why then they haven’t yet replaced blood transfusion at all?” We may say that in Europe the methods are adopted and widely used in treatment and operations of any kind on people of all ages (from 10-month child to 94-year-old woman). But in Russia this is a big problem…
    Why are Russian physicians so slow and reluctant in taking these methods in hand?
    There are several reasons I guess. The first reason is “peer pressure”. I know an anesthesiologist-obstetrician in Vyborg who was “for” alternative methods with all his heart. But when his counterparts had not accepted them, he “cooled off” and later transfused blood to a woman with his own hands (with not much useful results, by the way). The second reason is lack of professionalism. Excuse me but when you have an allergy on penicillin physician doesn’t refuse to cure you, he finds another way to help you. And this on its part requires mastery from him. The third reason for Russia may be unwillingness to part with old, “soviet” methods, hesitation to true something new. Of course, there is the government’s blame too. Many clinics cannot afford some of these methods

    ReplyDelete
  7. Natalya ZhilkevichApril 6, 2012 at 7:48 AM

    I suppose this article will leave no one indifferent. The article raised a serious problem that people may be wrong, but they are often convinced of their righteousness that leads to their wrong actions. Unfortunately, these people don't realize that their wrong actions may lead to fatal consequences. As well as the narrow-minded medical community criticized and mocked Semmelweis while thousands of women died.
    There is no doubt that Semmelweis was a genius. He raised an important problem of his time and his suggestion fundamentally revised the previously established methods of his counterparts. Now he is considered a pioneer of antiseptic procedures. But it is always difficult to be a pioneer of something. The history of science shows us that the old stereotypes are always hard to be broken.
    The expression "Semmelweis reflex" is used to name a certain type of human behavior characterized by reflex-like rejection of new knowledge because it contradicts established norms, beliefs or paradigms. But if there was a need in this expression, it means that there were the similar cases to be named after the Semmelweis' case and therefore we can conclude that such cases were quite frequent. And maybe if these situations were after Semmelweis, it is quite possible that such cases take place nowadays and may arise in the future.
    I don't clearly know how the process of introducing new ideas happens in modern scientific community, but I suppose that modern science is more flexible to new ideas in scantily explored areas of science which have no established paradigms. In these areas of science new knowledge doesn't conflict with the views of renowned scholars and therefore may not have many difficulties in its introducing. And to the contrast if new idea contradicts adopted methods and theories of well-known reputable scholars, it may lead to the "Semmelweis reflex" nowadays as it was 200 years ago.
    And why it happens in our world? Why a lot of people may be so unjust? And it will be better if a lot of modern people think not only about their own interests or benefits and often ask themselves: may we be wrong?

    ReplyDelete
  8. Very thoughtful. You paid attention to the title which is observing of you. Yes, that's what it means. The phrase is used in a broad sense nowadays, for example when talking about everyday situations when people are too stubborn or to proud to put up with being proven wrong.
    I agree there have to be matters more important than own interests or benefits. But HOW on earth are you going to prove to people that they MUST think not only about that?! They simply don't see a reason to change anything.

    ReplyDelete
    Replies
    1. Natalya ZhilkevichApril 27, 2012 at 3:22 PM

      I completely agree that it is hardly possible to prove anything to these people. And it is really true that they don't see a reason to change anything.

      Delete
  9. For my point of view nower days science is more flexible for new points of view.Why?The answer is very simple - Expirience.We can compare humanity with a child,in the very beginning "mind" is clear and you are afraid of everything.Thunder can kill you,and tribe of little dwarfs from your tv set for shure will steal your toys at night.But then you will go to scholl,then to university,you will gain expirience,you will gain knowledge,and then you will suddenly realise how all of these are working.(I must say that after this event your broblems will not dissapear,but on the contrary they will become more serious and global....but this is another story))).The same thing with humanity and science,after five thousands of burned and quartered,we are realised that those freaky(diabolic)) guy who is speaking about new type of oxygen working engine is not a total dumbass,but maybe are next Einstein.
    A.Alekseenkova.

    ReplyDelete
  10. This comment has been removed by a blog administrator.

    ReplyDelete
  11. I would like to argue about such a subject as "society blindness".
    To tell the truth I was very delighted by Dr. Semmelweis resistance. The doctor tried to challenge his point of view during all his life.
    Of course, his discovery turned other doctors into murderers .
    To my mind that was the main reason for which it was strongly and unequivocally rejected. You can imagine a state of despair which seized Dr. Semmelweis, this terrible feeling of helplessness.
    He couldn’t break through the wall of arrogance and traditions.He knew how to save the world from the disease, but the world remained deaf to his advice.
    As far as I know there is such a term in psychology as “Semmelweis effect" .It is a metaphor for the reflex-like tendency to reject new evidence or new knowledge because it contradicts established norms.
    This great person was underestimated and unfairly punished.
    Sometimes we just don't appreciate those great people who really care for us until we lose them.
    Of course we live in a modern society, our medicine has moved far ahead nevertheless we are suffering from different inexplicable diseases. What’s the reason?
    Perhaps we are surrounded by snobbery and cynicism, and do not notice the obvious things.
    Our moral behavior deteriorated and it is the cause of new diseases.
    "Diseases can be our spiritual flat tires - disruptions in our lives that seem to be disasters at the time but end by redirecting our lives in a meaningful way."-said famous Bernie S. Siegel.
    So you shouldnt forget that all the diseases come from inside!

    ReplyDelete
  12. Semmelweis was wrong. And all the modern medicine is wrong about the cause of childbed fever deaths.

    Those deaths were caused in fact by the practice of blood letting. Doctors took between 1,2 and 1,8 L (or even more) of blood immediately after having diagnosed a woman with puerperal fever. And just after that, they made a purge with calomel (mercury chloride) or other kinds of drugs. And if it wasn't enough to kill the patient, they gave him opiates (which provokes low blood pressure). So, what really happened is that those women were killed by the doctors.

    They died from extreme low blood pressure because of the blood letting, the purgative drugs, and opiates. Blood letting caused extreme low blood pressure, purgative drugs provoked an important low blood pressure because of the mobilization of blood in the digestive system, and opiate caused low blood pressure because of the dilation of blood vessels.

    Aixur

    ReplyDelete
    Replies
    1. An'Nega De La VegaJune 22, 2012 at 10:59 AM

      Where is this information from? And what about clean hands? Is there no difference if there are clean or durty? If a doctor has just worked with a corps and 5 minutes later he receives a child?

      Delete